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Related Experiment Videos

Group B streptococcal cellulitis-adenitis in infants

C J Baker

    American Journal of Diseases of Children (1960)
    |July 1, 1982
    PubMed
    Summary

    Group B Streptococcus (GBS) infections in infants often present as cellulitis-adenitis, with a potential link to otitis media. This suggests lymphatic spread, not just bacteremia, may cause these unusual GBS infections.

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    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Neonatology

    Background:

    • Group B Streptococcus (GBS) is a common cause of neonatal infections.
    • Cellulitis-adenitis is a recognized manifestation of GBS infection in infants.

    Observation:

    • Seven infants with GBS cellulitis-adenitis were studied, with a mean age of onset at five weeks.
    • Common symptoms included poor feeding or irritability (94%), with a male predominance (75%).
    • Bacteremia was present in 94% of cases, with Type III GBS implicated in 75%.

    Findings:

    • Unusual sites of GBS involvement included inguinal lymph nodes and a thyroglossal duct cyst.
    • A significant association was found between GBS cellulitis and ipsilateral otitis media (80%).
    • No antibody response to Type III GBS capsular antigen was detected in convalescent sera.

    Implications:

    • Otitis media may play a role in the pathogenesis of GBS cellulitis-adenitis via lymphatic spread.
    • This challenges the assumption of primary bacteremia as the sole cause of these infections.
    • Understanding alternative pathways can inform diagnostic and treatment strategies for GBS infections.

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