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Indicator dilution using a fluorescent indicator

V B Elings, F R Lewis, J Briggs

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |May 1, 1982
    PubMed
    Summary
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    This study introduces a novel fluorescent indicator and catheter system for accurate in vitro and in vivo dilution measurements. The new method shows promise for assessing lung water and heart shunts, with sensitivity to blood oxygen levels.

    Area of Science:

    • Cardiovascular physiology
    • Medical diagnostics
    • Biomedical engineering

    Background:

    • Indicator-dilution techniques are crucial for physiological measurements.
    • Existing methods like green dye-dilution have limitations.
    • Accurate quantification of extravascular lung water and cardiac shunts is clinically significant.

    Purpose of the Study:

    • To develop and validate a novel fluorescent indicator-dilution method for physiological measurements.
    • To compare the novel fluorescent method with established techniques like green dye-dilution and gravimetry.
    • To assess the sensitivity of the fluorescent method to blood parameters and its utility in detecting cardiac shunts.

    Main Methods:

    • Utilized a novel catheter with a single optical fiber for fluorescent light transmission and reception.

    Related Experiment Videos

  • Performed in vitro and in vivo indicator-dilution measurements using a fluorescent indicator.
  • Compared fluorescent-dilution measurements with simultaneous green dye-dilution and gravimetric measurements.
  • Investigated the impact of O2 saturation and hematocrit on fluorescent measurements.

    • Main Results:

    • Fluorescent-dilution measurements demonstrated good correlation with green dye-dilution and gravimetric methods.
    • The system showed sensitivity to changes in blood O2 saturation and hematocrit.
    • Successfully measured a right-to-left heart shunt using the fluorescent indicator.

    Conclusions:

    • The novel fluorescent indicator-dilution system offers a viable alternative for physiological measurements.
    • This technique is effective for quantifying extravascular lung water and detecting cardiac shunts.
    • The method's sensitivity to blood parameters enhances its clinical applicability.