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Quantitation of left ventricular dimensions and function by digital video subtraction angiography
Radiology
|August 1, 1982
Summary
Digital video subtraction angiography (DVSA) accurately quantifies cardiac function in animals and patients. This imaging technique precisely measures left ventricular dimensions and contractile performance, correlating well with established methods.
Area of Science:
- Cardiovascular Imaging
- Diagnostic Radiology
- Medical Physics
Background:
- Assessing left ventricular (LV) dimensions and contractile function is crucial for diagnosing and managing cardiovascular diseases.
- Traditional methods like left ventriculography can be invasive.
- There is a need for accurate, non-invasive or minimally invasive quantitative imaging techniques.
Purpose of the Study:
- To evaluate the accuracy and utility of digital video subtraction angiography (DVSA) for quantitating central cardiovascular physiology.
- To assess DVSA's ability to measure left ventricular dimensions and contractile function in experimental animals and human patients.
Main Methods:
- DVSA was performed following central intravenous contrast media administration in experimental animals and patients with suspected coronary artery disease.
- Measurements included left ventricular volumes, wall thickness, ejection fraction, segmental contraction, and cardiac output.
- In patients, DVSA results were compared with direct left ventriculography; in animals, comparisons were made with sonocardiometry and thermodilution.
Main Results:
- In animals, DVSA measurements of LV volumes, wall thickness, ejection fraction, segmental contraction, and cardiac output showed close correlation with sonocardiometry and thermodilution.
- In patients, DVSA-derived volumes and ejection fractions correlated well with direct left ventriculography.
- DVSA effectively displayed global and segmental contractile function using specialized imaging techniques (ejection shell, stroke volume, time interval difference images).
- Pulmonary transit time and pulmonary blood volume were also accurately quantitated using DVSA.
Conclusions:
- DVSA is a useful and accurate method for quantifying central cardiovascular physiology.
- The technique provides reliable measurements of left ventricular dimensions and contractile function.
- DVSA offers a valuable tool for assessing cardiovascular function in both experimental and clinical settings.