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Related Experiment Videos

A practical guide to interactions involving theophylline kinetics

J C McElnay, G D Smith, D K Helling

    Drug Intelligence & Clinical Pharmacy
    |July 1, 1982
    PubMed
    Summary

    This guide details drug interactions affecting theophylline levels and effects. Understanding these interactions, from pharmacokinetics to pharmacodynamics, is crucial for safe and effective asthma treatment.

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    Area of Science:

    • Pharmacology
    • Clinical Pharmacy

    Background:

    • Theophylline is a common bronchodilator for asthma.
    • Drug interactions can significantly alter theophylline's efficacy and safety.
    • A comprehensive understanding of these interactions is needed for optimal patient care.

    Purpose of the Study:

    • To provide a practical guide to drug interactions involving theophylline kinetics.
    • To classify these interactions based on pharmacokinetic, pharmacodynamic, and miscellaneous mechanisms.
    • To enhance awareness among prescribers regarding potential theophylline-related drug interactions.

    Main Methods:

    • Classification of interactions by pharmacokinetic site (in vitro, intestinal, metabolic, protein binding, renal).
    • Analysis of pharmacodynamic interactions, focusing on additive effects with other bronchodilators.
    • Review of miscellaneous interactions, including those with allergic skin testing and assay methods.

    Main Results:

    • Drug interactions affect theophylline pharmacokinetics through various mechanisms.
    • Pharmacodynamic interactions can lead to additive bronchodilator effects.
    • Miscellaneous interactions can impact diagnostic tests and therapeutic monitoring.

    Conclusions:

    • Increased awareness of theophylline drug interactions is essential for critical prescribing.
    • Monitoring for unexpected therapeutic effects or serum concentrations is vital in asthma patients.
    • This guide aims to improve the safe and effective use of theophylline in clinical practice.

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