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Related Experiment Videos

Penicillamine-induced polymyositis-dermatomyositis

J Petersen, P Halberg, K Højgaard

    Scandinavian Journal of Rheumatology
    |January 1, 1978
    PubMed
    Summary

    Penicillamine treatment for rheumatoid arthritis can cause myopathy, a muscle disorder. Symptoms improved in both patients after discontinuing the drug, indicating a potential adverse effect.

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    Area of Science:

    • Rheumatology
    • Neurology
    • Immunology

    Background:

    • Rheumatoid arthritis (RA) is a chronic autoimmune disease.
    • Penicillamine is a chelating agent used in treating RA.
    • Drug-induced myopathy is a known, albeit rare, adverse effect of certain medications.

    Observation:

    • Two patients with RA developed muscle weakness during penicillamine therapy.
    • Electromyography and muscle biopsies confirmed polymyositis in both cases.
    • One patient exhibited a rash, with skin biopsies showing immunoglobulin and complement deposits.

    Findings:

    • Penicillamine-induced myopathy is a potential complication in RA patients.
    • Muscle enzyme levels were elevated in one patient, suggesting active muscle inflammation.
    • Histopathological findings in skin support an immune-mediated process.

    Implications:

    • Discontinuation of penicillamine is crucial for managing drug-induced myopathy.
    • Awareness of this adverse effect is important for clinicians treating RA patients.
    • Further research may elucidate the immunopathogenesis of penicillamine-induced myopathy.

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