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Cimetidine dynamics after single intravenous doses

S Pancorbo, M P Bubrick, T W Chin

    Clinical Pharmacology and Therapeutics
    |January 1, 1982
    PubMed
    Summary
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    This study investigated cimetidine pharmacokinetics in trauma patients. Cimetidine concentrated in gastric fluid, showing a correlation with gastric pH, which is crucial for understanding drug behavior in critically ill patients.

    Area of Science:

    • Pharmacology
    • Critical Care Medicine
    • Gastroenterology

    Background:

    • Cimetidine is a histamine H2 receptor antagonist used to reduce gastric acid production.
    • Understanding cimetidine pharmacokinetics is essential in critically ill patients, particularly those with multiple trauma, due to altered physiological states.
    • Gastric pH significantly influences the absorption and efficacy of many medications.

    Purpose of the Study:

    • To characterize the pharmacokinetic profile of cimetidine in multiple-trauma patients.
    • To investigate the relationship between plasma cimetidine concentrations, gastric fluid concentrations, and gastric pH.
    • To determine the extent of cimetidine distribution into gastric fluid.

    Main Methods:

    • Pharmacokinetic analysis of cimetidine in nine multiple-trauma patients.

    Related Experiment Videos

  • Measurement of plasma and gastric fluid cimetidine concentrations over time.
  • Correlation analysis between drug concentrations, gastric pH, and pharmacokinetic parameters.

    • Main Results:

    • Mean cimetidine elimination half-life was 2.27 hr, with a total body clearance of 9.02 ml/min/kg.
    • Cimetidine achieved peak concentrations in gastric fluid within 3 hours after intravenous administration.
    • Gastric fluid cimetidine concentrations were significantly higher than plasma concentrations (ratios 3.0-4.3), correlating with gastric pH (r=0.50).

    Conclusions:

    • Cimetidine exhibits significant distribution into gastric fluid in multiple-trauma patients.
    • Gastric pH influences cimetidine concentration in gastric fluid, suggesting potential implications for acid suppression therapy efficacy.
    • These findings highlight the importance of considering gastric pH in the management of cimetidine therapy in critically ill trauma patients.