Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunological Memory01:23

Immunological Memory

14.9K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
14.9K
Development of Immunocompetence01:22

Development of Immunocompetence

769
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
769
Rh Blood Group01:19

Rh Blood Group

2.7K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
2.7K
Active versus Passive Immunity01:31

Active versus Passive Immunity

9.9K
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
9.9K
Vaccinations01:51

Vaccinations

51.1K
Overview
51.1K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

8.4K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

International infrastructure to control infectious diseases.

World journal of microbiology & biotechnology·2014
Same author

Inquiry into hereditary factors in the pathogenesis of dengue haemorrhagic fever: a preliminary note.

Bulletin of the World Health Organization·2010
Same author

Attempts at virus recovery from patients dying of Thai haemorrhagic fever.

Bulletin of the World Health Organization·2010
Same author

Tissue culture techniques for the study of dengue viruses.

Bulletin of the World Health Organization·2010
Same author

Recovery of dengue and chikungunya viruses from Thai haemorrhagic fever patients by passage in sucking mice.

Bulletin of the World Health Organization·2010
Same author

Recovery of dengue and other viruses in mice and tissue culture from Thai mosquitos.

Bulletin of the World Health Organization·2010
Same journal

WHO Issues Guidelines for Treating Ebola and Marburg Viruses.

JAMA·2026
Same journal

FDA Approves Additional Naloxone Nasal Spray for Opioid Overdose.

JAMA·2026
Same journal

HIV May Hide in More Cells Than Previously Thought-Here's What That Could Mean for a Cure.

JAMA·2026
Same journal

US Dietary Supplement Use Increasing, Especially in Older Adults.

JAMA·2026
Same journal

Heat Stress From Climate Change Surges Globally.

JAMA·2026
Same journal

Strength Training Linked With Lower Cardiovascular Disease Risk in Women.

JAMA·2026
See all related articles

Related Experiment Videos

Rubella antibody persistence after immunization

K L Herrmann, S B Halstead, N H Wiebenga

    JAMA
    |January 8, 1982
    PubMed
    Summary
    This summary is machine-generated.

    This study tracked rubella virus vaccine immunity for ten years. Results show high antibody persistence and stable immunity in over 97% of vaccine recipients.

    Related Experiment Videos

    Area of Science:

    • Virology
    • Immunology
    • Public Health

    Background:

    • Rubella virus poses a significant public health concern.
    • Live, attenuated rubella virus vaccines are crucial for disease prevention.
    • Assessing long-term vaccine-induced immunity is essential for public health strategies.

    Purpose of the Study:

    • To evaluate the durability of immunity induced by three live, attenuated rubella virus vaccines.
    • To assess long-term serological responses following vaccination.
    • To determine the persistence of hemagglutination-inhibition (HI) antibody titers over a ten-year period.

    Main Methods:

    • A comparative field trial involving three rubella virus vaccines: Cendehill, HPV 77 DE-5, and HPV-77 DK-12.
    • Initiated in 1969 with initial seroconversion assessment.
    • Periodic serological testing (HI titers) conducted over ten years on a cohort of vaccinees.

    Main Results:

    • Initial seroconversion rates exceeded 98% for all vaccine groups.
    • Mean HI titers dropped by approximately 50% in the first four years, then stabilized.
    • Antibody levels remained stable between years 4 and 10, with less than 0.5% annual reversion to low titers.
    • Over 97% of vaccinees maintained measurable HI antibody levels throughout the ten-year study period.

    Conclusions:

    • Live, attenuated rubella virus vaccines induce high initial seroconversion rates.
    • Potent rubella vaccines, when administered properly, provide durable, long-lasting immunity.
    • High rates of antibody persistence support the long-term efficacy of rubella vaccination.