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Updated: Jun 23, 2026
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Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs
Published on: March 5, 2016
Luminal lymphoid cells in the rabbit intestine
Gastroenterology
|February 1, 1982
Summary
Lymphocytes and macrophages are found in the rabbit appendix lumen, interacting with gut microbes. This suggests normal, antigen-responsive migration of immune cells from gut-associated lymphoid tissue into the intestinal lumen.
Area of Science:
- Immunology
- Gastroenterology
- Microbiology
Background:
- Lymphocytes are present in the Peyer's patches and appendix of rabbits.
- Luminal cells exhibit close contact with intestinal microorganisms.
Purpose of the Study:
- To investigate the presence and characteristics of lymphocytes in the appendiceal lumen.
- To understand the migration patterns and functional significance of these cells.
Main Methods:
- Scanning and transmission electron microscopy were used to identify luminal lymphocytes.
- Appendiceal lumen irrigation was employed to collect and analyze cells.
- In vivo cytokinetic studies assessed lymphocyte proliferation.
Main Results:
- Large numbers of lymphocytes and macrophages were identified in the appendiceal lumen.
- Collected cells showed functional characteristics similar to intestinal mucosal cells.
- 50% of luminal lymphocytes were recently divided, indicating active cell traffic.
- Lymphoid cell migration into the lumen was antigen-responsive.
Conclusions:
- The appendix lumen serves as a site for normal lymphocyte and macrophage traffic.
- This migration likely originates from gut-associated lymphoid tissue.
- Intestinal mucosal surfaces may be significant for immune cell circulation, similar to the bronchial tract.
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