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Selenium sulfide: adjunctive therapy for tinea capitis

H B Allen, P J Honig, J J Leyden

    Pediatrics
    |January 1, 1982
    PubMed
    Summary
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    Selenium sulfide shampoo, used alongside griseofulvin, effectively treats tinea capitis in children. This combination therapy led to negative fungal cultures in most patients within two weeks, unlike other treatments.

    Area of Science:

    • Dermatology
    • Mycology
    • Pediatrics

    Background:

    • Tinea capitis is a common fungal infection of the scalp, particularly in children.
    • Griseofulvin is a standard oral antifungal medication for tinea capitis.
    • Adjunctive therapies are explored to improve treatment efficacy and reduce transmission.

    Purpose of the Study:

    • To evaluate the efficacy of selenium sulfide lotion as an adjunctive treatment for tinea capitis.
    • To compare the effectiveness of griseofulvin with and without selenium sulfide shampoo.

    Main Methods:

    • A study involving 16 children with Trichophyton tonsurans tinea capitis.
    • Treatment groups included daily oral griseofulvin with selenium sulfide shampoo (twice weekly) or griseofulvin alone/with bland shampoo/clotrimazole.

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  • Fungal cultures were assessed at two and eight weeks.

    • Main Results:

    • 15 out of 16 children achieved negative fungal cultures at two weeks with the griseofulvin and selenium sulfide combination.
    • Patients receiving griseofulvin alone or with other comparators had persistent positive cultures up to eight weeks.
    • In vitro tests confirmed selenium sulfide's sporicidal activity.

    Conclusions:

    • Selenium sulfide shampoo is an effective adjunctive therapy for griseofulvin in treating tinea capitis.
    • This combination may reduce the duration of infection and the potential for spore transmission.
    • The sporicidal action of selenium sulfide supports its clinical efficacy.