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Effect of protamine on plasma ionized calcium in the dog
Canadian Anaesthetists' Society Journal
|January 1, 1982
Abstract:
The anaesthetized, heparinized health adult dogs were infused with protamine sulphate 3 mg X kg-1 and plasma ionized calcium was measured. A significant (p less than 0.01) decrease in ionized calcium occurred which preceded the maximal reduction in cardiac output and systemic arterial pressure. The clinical implications of these results are discussed.