The quantitative structure-activity relationship of rifamycin B amide and hydrazide toxicity in mice

Quantitative structure-activity relationships (QSAR) are developed for the acute toxicity of a number of rifamycin B amides and hydrazides in mice. The equations indicate a parabolic dependence of toxicity on the partition coefficient. Two related compounds, rifamycin SV and rifamycin B, were included with the amides in a more general correlation. The latter equation was used to predict the toxicity of rifampicin, suggesting that this relationship may be of general use for the prediction of rifamycin toxicity.