Synthesis of isotopically labeled saturated fatty acids

An approach to the synthesis of isotopically labeled saturated fatty acids is outlined which is based on the copper-catalyzed coupling of an omega-bromo acid with an isotopically labeled Grignard reagent. The method provides high yields of pure products and offers considerable flexibility in the type of isotopically enriched compound that can be prepared.-DasGupta, S. K., D. M. Rice, and R. G. Griffin. Synthesis of isotopically labeled saturated fatty acids.