The management of meibomian gland carcinoma

We present nine cases of sebaceous adenocarcinoma seen on the Oculoplastic Service at the University of Iowa over the past five years. It is essential to make the biopsy-proven diagnosis of meibomian gland adenocarcinoma promptly, using multiple full thickness eyelid biopsies. We recommend the Mohs' fresh-frozen technique in patients with surgically resectable lesions, exenteration in those with orbital extension, and radical neck dissection for cases with nodal involvement. Radiotherapy may be indicated in patients with extensive tumors who cannot tolerate or refuse surgery or as an adjunct to surgery in others.