[Phosphorylase activity in Rana ridibunda tissue during hibernation, prolonged hypothermia and heating]

Essential seasonal changes are found in the total activity of phosphorylase and the activity of its forms in the Rana ridibunda tissues. They are mostly pronounced in the liver and myocardium tissues. A week hibernation (2-4 degrees C) and artificial hypothermia (2-4 degrees C) of the same duration cause changes of different direction in the phosphorylases a and b ratio in the musculus trapezius and myocardium of frogs. Healing after hypothermia, as distinct from heating after hibernation, increases the enzyme total activity in all the tissues under study as well as the phosphorylase alpha activity in the skeletal muscles and myocardium. When the animal awakes from hibernation the enzyme activity increases only in the liver tissue due to the inactive form.