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Related Experiment Videos

Malignant external otitis and polymorphonuclear leukocyte migration impairment. Improvement with ascorbic acid

J Corberand, F Nguyen, B Fraysse

    Archives of Otolaryngology (Chicago, Ill. : 1960)
    |February 1, 1982
    PubMed
    Summary

    Malignant external otitis (MEO) in diabetic patients may involve impaired polymorphonuclear neutrophil leukocyte (PMN) function. Vitamin C treatment improved PMN migration and healed ear lesions, suggesting its potential as an immunomodulator.

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    Area of Science:

    • Infectious Diseases
    • Immunology
    • Otolaryngology

    Background:

    • Malignant external otitis (MEO) is a severe Pseudomonas aeruginosa infection of the ear canal.
    • MEO disproportionately affects elderly individuals with uncontrolled diabetes mellitus.
    • High mortality rates suggest underlying host defense mechanism deficits.

    Observation:

    • A 58-year-old male patient with MEO presented with impaired polymorphonuclear neutrophil leukocyte (PMN) migration.
    • Standard treatments were ineffective for several months.
    • In vitro studies demonstrated ascorbic acid (vitamin C) improved PMN migration capabilities.

    Findings:

    • The patient received a one-month course of ascorbic acid therapy.
    • Chemotaxis test results normalized concurrently with clinical improvement.

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  • Ear lesions healed following ascorbic acid treatment and normalization of PMN function.

    • Implications:

    • PMN function assessment is crucial for MEO patients.
    • Ascorbic acid may serve as an effective immunomodulatory treatment for MEO.
    • Further research is needed to elucidate the mechanisms linking diabetes, aging, infection, and PMN dysfunction in MEO.