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Antihypertensive action of acebutolol (Sectral) when used concomitantly with hydrochlorothiazide
Insights
Hydrochlorothiazide effectively lowers blood pressure in patients with essential hypertension. Adding acebutolol further reduces blood pressure, demonstrating its efficacy as an anti-hypertensive agent.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Essential hypertension is a common condition requiring effective treatment.
- Diuretics and beta-blockers are established anti-hypertensive drug classes.
Purpose of the Study:
- To evaluate the anti-hypertensive effects of hydrochlorothiazide alone and in combination with acebutolol.
- To assess the dose-response relationship of acebutolol when added to hydrochlorothiazide therapy.
Main Methods:
- A placebo-controlled study involving 18 patients with moderately severe essential hypertension.
- Patients received hydrochlorothiazide, followed by the addition of acebutolol in escalating doses.
- Blood pressure was monitored in a supine position throughout the study.
Main Results:
- Hydrochlorothiazide (100 mg daily) reduced mean supine blood pressure from 163/107 mmHg to 150/103 mmHg.
- Adding acebutolol (up to 800 mg daily) further decreased mean supine blood pressure to 137/95 mmHg.
- Increased acebutolol dosage (up to 2000 mg daily) in 13 patients lowered blood pressure to 132/92 mmHg.
Conclusions:
- Hydrochlorothiazide demonstrates significant anti-hypertensive effects in essential hypertension.
- Combination therapy with hydrochlorothiazide and acebutolol provides additive blood pressure reduction.
- Acebutolol is effective in further controlling hypertension not adequately managed by hydrochlorothiazide alone.
Abstract:
1 In a placebo-controlled study, the respective anti-hypertensive effects of hydrochlorothiazide and hydrochlorothiazide plus the beta-adrenoceptor blocker acebutolol were assessed in 18 patients with moderately severe essential hypertension. 2 Hydrochlorothiazide 100 mg daily decreased the mean supine blood pressures from 163/107 mmHg to 150/103 mmHg. Addition of acebutolol in a single-blind fashion in doses up to 800 mg daily reduced mean supine pressure to 137/95 mmHg. Further increases in acebutolol dosage to a maximum of 2000 mg daily in 13 patients whose hypertension was not well controlled on lower doses resulted in a mean supine blood pressure of 132/92 mmHg.