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Related Experiment Videos

Cocaine self-administration in humans

M W Fischman, C R Schuster

    Federation Proceedings
    |February 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Healthy volunteers consistently chose cocaine over saline in self-administration studies. This research provides a comprehensive profile of cocaine's effects in humans, integrating behavioral and physiological data.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Human Physiology

    Background:

    • Cocaine is a potent stimulant with significant abuse potential.
    • Understanding cocaine's effects in humans is crucial for addiction research and public health.
    • Previous research has established cocaine's physiological and behavioral impact, but comprehensive human data is needed.

    Purpose of the Study:

    • To comprehensively profile the physiological and behavioral effects of intravenous cocaine in healthy human volunteers.
    • To investigate cocaine's abuse liability through self-administration paradigms.
    • To correlate plasma cocaine levels with observed effects.

    Main Methods:

    • Intravenous administration of varying cocaine and d-amphetamine doses to healthy volunteers.

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  • Monitoring of physiological parameters: heart rate, ECG, blood pressure, respiration, temperature.
  • Assessment of behavioral effects using the Profile of Mood States and Addiction Research Center Inventory.
  • Cocaine vs. saline choice task for self-administration assessment.
  • Plasma cocaine level monitoring.

    • Main Results:

    • Cocaine administration led to dose-dependent changes in physiological and mood states.
    • Subjects consistently preferred intravenous cocaine over saline in self-administration tasks.
    • Subjective and cardiovascular effects were documented, correlating with plasma cocaine levels.

    Conclusions:

    • Cocaine exhibits a high abuse potential in humans, evidenced by consistent self-administration.
    • The study provides a detailed human pharmacological profile of cocaine, integrating subjective, behavioral, and physiological data.
    • Findings contribute to understanding cocaine's actions and informing addiction treatment strategies.