The biocompatibility of polypyrrolidone in test implantation

The biological compatibility of polypyrrolidone was investigated using subcutaneous implantation in rats. Acute (10 days) and chronic (360 days after implantation) tissue reaction was characterized numerically and compared with poly(2-hydroxyethyl methacrylate), used in the Drug Control Research Institute in Prague as a standard in the evaluation of polymers, for which good tolerance in the clinical practice has been demonstrated. Surface changes in the polymer were evaluated by using a scanning electron microscope.