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Quantitative analysis of ethynodiol diacetate and ethinyl estradiol/mestranol in oral contraceptive tablets by
Journal of Pharmaceutical Sciences
|February 1, 1982
Abstract:
A procedure is described for the assay of ethynodiol diacetate and ethinyl estradiol/mestranol by HPLC using two UV detectors at 210 and 280 nm. The system was acetonitrile 38% (v/v) in water as mobile phase on a 250 x 3.2-mm i.d. RP-2 column, with butylated hydroxytoluene as the internal standard. There was greater than 99% recovery from synthetic preparations and the coefficient of variation was greater than 2.0% for formulations.
Keywords:
ContraceptionContraceptive Agents, EstrogenContraceptive Agents, FemaleContraceptive Agents, ProgestinContraceptive Agents--analysisEthinyl EstradiolEthynodiol Diacetate--analysisEvaluationExaminations And DiagnosesFamily PlanningLaboratory Examinations And DiagnosesLaboratory ProceduresMestranol