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Related Experiment Videos

Volume determinations in computed tomography

D E Brenner, N O Whitley, T L Houk

    JAMA
    |March 5, 1982
    PubMed
    Summary
    This summary is machine-generated.

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    Computed tomography (CT) accurately estimates the volume of masses, showing changes comparable to clinical exams. This technique aids in monitoring tumor response to therapy.

    Area of Science:

    • Radiology
    • Medical Imaging
    • Oncology

    Background:

    • Modern computed tomography (CT) scanners offer high-resolution cross-sectional imaging of organs and masses.
    • Accurate volume estimation is crucial for assessing disease progression and treatment efficacy.

    Observation:

    • CT volume estimation accuracy was assessed using inanimate objects, cadaver organs, and in vivo balloons.
    • A two-step process involved outlining regions of interest and calculating volume using Simpson's rule.
    • Calculated CT volumes demonstrated a high degree of accuracy, within +/-10% of directly measured volumes.

    Findings:

    • CT-derived volume changes in tumor masses undergoing chemotherapy were comparable and often more sensitive than clinical examinations.
    • Factors influencing CT volume estimation accuracy include respiratory motion, blood volume fluctuations, object edge definition, and observer variability.

    Related Experiment Videos

  • Mathematical limitations inherent in Simpson's rule can also affect precision.

    • Implications:

    • Computed tomography provides a reliable method for estimating the volume of identifiable masses.
    • CT-based volume assessment is a valuable tool for monitoring tumor response to therapeutic interventions.
    • This technique enhances the ability to track treatment effectiveness in oncology.