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Related Experiment Videos

Interlaboratory bilirubin variability

R L Schreiner, M R Glick

    Pediatrics
    |March 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    High interlaboratory variability in bilirubin testing was observed. Stabilized liquid quality control sera can help reduce these discrepancies in total and conjugated bilirubin analyses.

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    Area of Science:

    • Clinical Chemistry
    • Laboratory Medicine
    • Analytical Chemistry

    Background:

    • Accurate bilirubin measurement is crucial for diagnosing and monitoring liver conditions and hemolytic diseases.
    • Significant interlaboratory variability in bilirubin testing has been reported, potentially impacting patient care.
    • Existing quality control materials may not adequately address the challenges in bilirubin analysis.

    Purpose of the Study:

    • To evaluate the effectiveness of stabilized liquid quality control sera in reducing interlaboratory variability for bilirubin measurements.
    • To assess the performance of these sera in both total and conjugated bilirubin assays across different laboratories.

    Main Methods:

    • Distribution of stabilized liquid quality control sera with varying bilirubin concentrations to multiple clinical laboratories.

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  • Analysis of total and conjugated (direct) bilirubin concentrations using standard laboratory methods.
  • Statistical analysis of interlaboratory variability, including calculation of coefficients of variation.

    • Main Results:

    • High interlaboratory variability was observed, with wide result ranges for specific bilirubin concentrations.
    • Coefficients of variation were substantial, particularly for conjugated bilirubin analyses (approximately 24%).
    • Total bilirubin analyses showed variability between 10% and 12%.

    Conclusions:

    • Stabilized liquid quality control sera demonstrate potential as valuable tools for improving bilirubin testing accuracy.
    • Consistent use of these sera can help mitigate the significant interlaboratory variability identified in bilirubin assays.
    • Further adoption of these quality control materials is recommended to enhance diagnostic reliability.