A simple and rapid test for PIVKA-II in plasma

A simple and rapid assay for the detection of PIVKA-II is described. The principle of the assay is based on agglutination of antihuman prothrombin rabbit IgG coated latex with absorbed plasma which is treated with barium carbonate. This assay is expected to be useful as a screening test to differentiate whether or not vitamin K deficiency is present in various clinical cases such as newborn infants, patients with liver diseases, disseminated intravascular coagulation, and so on.