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ABH secretor status and pulmonary function

A P Haines, J D Imeson, T W Meade

    American Journal of Epidemiology
    |March 1, 1982
    PubMed
    Summary
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    Secretors of ABH antigen, a substance in bodily fluids, showed higher lung function in current cigarette smokers. This suggests ABH antigen secretion may protect the respiratory tract from smoking-related damage.

    Area of Science:

    • Pulmonary Medicine
    • Immunogenetics

    Background:

    • Peak expiratory flow rate (PEFR) is a key indicator of lung function.
    • ABH antigens are genetically determined substances found in secretions, including those in the respiratory tract.
    • The role of ABH antigen secretor status in respiratory health, particularly in smokers, is not fully understood.

    Purpose of the Study:

    • To investigate the association between ABH antigen secretor status and lung function (PEFR) in different smoking groups.
    • To determine if ABH antigen secretion influences the impact of smoking on pulmonary health.

    Main Methods:

    • Analysis of data from the Northwick Park Heart Study.
    • Comparison of mean PEFR between secretors and nonsecretors of ABH antigen.
    • Stratification of analysis by smoking status (current smokers, ex-smokers, non-smokers, pipe/cigar smokers).

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    Main Results:

    • Current cigarette smokers who were secretors of ABH antigen exhibited a significantly higher mean PEFR compared to nonsecretors.
    • This association remained significant after adjusting for other factors influencing PEFR.
    • No significant differences in PEFR by secretor status were observed in non-smokers or pipe and cigar smokers.
    • A smaller, non-significant difference in PEFR was noted between secretors and nonsecretors among ex-cigarette smokers.

    Conclusions:

    • Secretion of ABH antigen into the respiratory tract may confer a protective effect against pulmonary damage induced by noxious agents, such as those in cigarette smoke.
    • ABH antigen secretor status could be a relevant factor in modulating the respiratory health consequences of cigarette smoking.