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Relation between intestinal blood flow and oxygen uptake

P R Kvietys, D N Granger

    The American Journal of Physiology
    |March 1, 1982
    PubMed
    Summary
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    Intestinal oxygen uptake in canine ileum remains independent of blood flow within a specific range. Vasodilators like isoproterenol do not alter oxygen uptake unless they affect cellular metabolism.

    Area of Science:

    • Physiology
    • Gastroenterology
    • Pharmacology

    Background:

    • Intestinal oxygen uptake is crucial for maintaining tissue function.
    • Understanding the relationship between blood flow and oxygen consumption is vital for assessing intestinal health.
    • The effects of vasodilators on intestinal oxygen metabolism require further elucidation.

    Purpose of the Study:

    • To investigate the relationship between blood flow and oxygen uptake in the canine ileum.
    • To determine the impact of vasodilators (isoproterenol, adenosine, 2,4-dinitrophenol) on ileal oxygen consumption.
    • To explore the autoregulation of intestinal oxygen uptake.

    Main Methods:

    • Experiments were conducted on autoperfused and pump-perfused canine ileum preparations.
    • Measurements included arterial pressure, venous outflow pressure, blood flow, and arteriovenous oxygen difference.

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  • Blood flow was manipulated mechanically and via intra-arterial infusions of vasodilators.

    • Main Results:

    • Ileal oxygen uptake was independent of blood flow between 30-140 ml/min/100g in pump-perfused preparations.
    • Oxygen uptake became dependent on blood flow below 30 ml/min/100g.
    • Isoproterenol did not affect ileal oxygen uptake, adenosine decreased it, and 2,4-dinitrophenol increased it, consistent with in vitro findings.

    Conclusions:

    • Ileal oxygen uptake is largely independent of blood flow in autoperfused preparations within a physiological range.
    • Vasodilators do not alter intestinal oxygen uptake unless they directly impact oxidative metabolism.
    • These findings have implications for understanding intestinal perfusion and metabolic regulation.