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Related Experiment Videos

Methotrexate and ultraviolet radiation

R B Armstrong, M B Poh-Fitzpatrick

    Archives of Dermatology
    |March 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Methotrexate can cause sunburn reactivation, a side effect particularly relevant for patients undergoing phototherapy or photochemotherapy. This reaction is observed in both cancer patients and those with psoriasis receiving combined treatments.

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    Area of Science:

    • Dermatology
    • Oncology
    • Rheumatology

    Background:

    • Methotrexate is a common chemotherapy agent also used for autoimmune conditions like psoriasis and arthritis.
    • Phototherapy and photochemotherapy (e.g., coal tar with UV radiation) are established treatments for various skin conditions.

    Observation:

    • A sunburn reactivation phenomenon has been documented following methotrexate administration in cancer patients.
    • A similar reaction occurred in a patient with psoriasis undergoing combined coal tar/UV radiation and methotrexate therapy.

    Findings:

    • Methotrexate can induce or exacerbate skin reactions, specifically sunburn-like responses, in patients exposed to ultraviolet radiation.
    • This side effect highlights a potential interaction between methotrexate and phototherapy/photochemotherapy.

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    Implications:

    • Physicians using methotrexate, especially in conjunction with phototherapy or photochemotherapy, must be aware of this potential adverse effect.
    • Further research is needed to understand the mechanisms behind methotrexate-induced photosensitivity and sunburn reactivation.