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[Determination of the number of GC-pairs "recognized" by actinomycin D during binding with DNA]
Biofizika
|January 1, 1982
Abstract:
Experimental studies are reported on the binding of actinomycin D to various synthetic and naturally occurring DNAs. The experimental data obtained agree with a model in which the antibiotic molecule carries only one GC-specific reaction center and covers 5 base pairs upon binding to DNA. Positive cooperative effects are observed for the binding of actinomycin to poly(dG-dC)-poly (dG-dC) duplex.