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[Effect of vulcanizing accelerants on embryolethality in rats]
Biulleten' Eksperimental'Noi Biologii I Meditsiny
|January 1, 1982
Summary
Rubber accelerators (RA) can harm rat reproduction and cause embryonal lethality. Altax, in particular, demonstrated significant mutagenic and embryotoxic effects, impacting all measured lethality types.
Area of Science:
- Toxicology
- Reproductive toxicology
- Developmental toxicology
Background:
- Rubber accelerators (RA) are industrial chemicals with potential health risks.
- Previous studies have indicated possible adverse effects of RAs on reproductive health.
- Limited data exists on the specific impact of various RAs on embryonal lethality in rats.
Purpose of the Study:
- To investigate the effects of different rubber accelerators (captax, altax, santocure, santocure-mor, thiurams D and E) on embryonal lethality in rats.
- To assess the impact of RA administration on the reproductive cycle and conception rates in non-pregnant rats.
- To compare the mutagenic and embryotoxic potential of the tested RAs.
Main Methods:
- Administration of specific rubber accelerators to non-pregnant and pregnant Wistar rats.
- Monitoring of estrous cycles, conception rates, and various types of embryonal lethality (total, postimplantation).
- Assessment of mutagenicity indices for comparison with known mutagens.
Main Results:
- Administration of RAs to non-pregnant rats increased estrous cycle length and decreased conception rates.
- All tested RAs increased total embryonal lethality.
- Altax uniquely increased postimplantation lethality and demonstrated mutagenicity comparable to carcinogens.
Conclusions:
- Rubber accelerators can adversely affect rat reproductive function, leading to increased embryonal lethality.
- Altax exhibits the most potent embryotoxic and mutagenic effects among the tested RAs.
- The reproductive toxicity is attributed to the mutagenic, embryotic, and gonadotropic actions of these chemicals.