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[Cardiolipin antibodies in pregnancy of high risk]
Insights
Cardiolipin antibodies (CAb) are linked to adverse outcomes in high-risk pregnancies, including fetal death and intrauterine growth restriction. These antibodies may contribute to complications such as hypertension and recurrent miscarriages.
Area of Science:
- Obstetrics and Gynecology
- Immunology
- Perinatal Medicine
Background:
- High-risk pregnancies present complex challenges in perinatal care.
- Cardiolipin antibodies (CAb) are implicated in various autoimmune and thrombotic conditions.
Purpose of the Study:
- To investigate the prevalence and significance of cardiolipin IgG and IgM antibodies (CAb) in high-risk pregnancies.
- To determine the association between CAb and specific gestational complications.
Main Methods:
- Study included 116 high-risk pregnant women at a regional perinatal center.
- Cardiolipin IgG and IgM antibodies (CAb) were assessed.
- Association with outcomes like fetal death, hypertension, abortions, infertility, gestosis, and growth retardation was analyzed.
Main Results:
- CAb were found in 50% of cases with antenatal fetal death.
- Prevalence of CAb was noted in 21.4% with hypertension, 20% with habitual abortions, 20% with infertility history, and 15.2% with gestational gestosis.
- Intrauterine growth retardation was associated with CAb in 33.3% of cases.
- CAb were also observed in women with high uterine vascular resistance.
Conclusions:
- Cardiolipin antibodies (CAb) play a role in the development of gestational complications in high-risk pregnancies.
- Elevated CAb levels are associated with adverse pregnancy outcomes, including fetal demise and growth restriction.
- Further research is warranted to elucidate the precise mechanisms and guide clinical management.
Abstract:
Cardiolipin IgG and IgM antibodies (CAb) were studied in 116 cases of high-risk pregnancy. All the women were undergoing examination or treatment in regional perinatal center. CAb occurred more frequently in antenatal fetal death (50%). In blood hypertension, habitual abortions, history of infertility, gestational gestosis, CAb were encountered in 21.4, 20, 20 and 15.2% of cases, respectively. Intrauterine growth retardation was associated with CAb in 33.3% of cases. CAb occurred in pregnant women of different groups who had high uterine vascular resistance. The above findings indicate CAb contribution to genesis of gestational complications in high risk pregnancy.