Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Screening for multiple myeloma using routine laboratory test results

M Kitamura, H Yamaguchi, K Murakawa

Clinical Biochemistry

|February 1, 1982

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dynamic aspects of AMPs in the kidney in physiological conditions--their metabolism and turnover.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie·1992

Same author

[Activity of Enterococcus faecalis (FK-23) preparation as a biological response modifier].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·1992

Same author

[Clinical study on the time courses of serum myosin light chain I levels in patients with acute myocardial infarction: effect of intracoronary thrombolysis on serum myosin light chain I levels].

Kaku igaku. The Japanese journal of nuclear medicine·1992

Same author

Different patterns of cell volume regulation in hyposmotic media between attached and suspended HeLa cells.

Biochimica et biophysica acta·1992

Same author

Epitope homology between bacterial heat shock protein and self-proteins in the host cell.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·1992

Same author

A study on bone induction in hydroxyapatite combined with bone morphogenetic protein.

Plastic and reconstructive surgery·1992

This study developed a practical screening method for multiple myeloma using routine lab tests. Abnormal flocculation tests and hyperglobulinemia can indicate myeloma, prompting further investigation with serum electrophoresis.

Area of Science:

Hematology
Clinical Chemistry
Oncology

Background:

Multiple myeloma diagnosis relies on detecting myeloma protein, often identified via serum electrophoresis.
Routine laboratory work may reveal hyperglobulinemia or abnormal flocculation tests, suggesting potential myeloma.

Purpose of the Study:

To develop an efficient and practical screening method for multiple myeloma.
To identify a formula for discriminating multiple myeloma from other diseases using routine laboratory data.

Main Methods:

Analyzed data from 38 multiple myeloma patients' initial examinations.
Developed a discriminative formula based on thymol turbidity test (TTT) and zinc sulfate turbidity test (ZTT) results.
Combined the formula with serum electrophoresis for a comprehensive screening approach.

Related Experiment Videos

Main Results:

Identified 38 multiple myeloma cases over five years, significantly increasing observed incidence.
Most identified cases were in subclinical conditions, highlighting the need for early screening.
A formula was derived to differentiate multiple myeloma from other conditions based on TTT and ZTT.

Conclusions:

Routine laboratory tests can aid in the early detection of multiple myeloma.
A combined screening strategy using a derived formula and serum electrophoresis offers an efficient diagnostic pathway.
This approach facilitates the identification of multiple myeloma, particularly in its subclinical stages.