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Related Experiment Videos

Regional enteritis and HLA concordance in multiple siblings

J L Achord, C H Gunn, J F Jackson

    Digestive Diseases and Sciences
    |April 1, 1982
    PubMed
    Summary

    Familial Crohn

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    Severe hepatic necrosis associated with methyldopa.

    Canadian family physician Medecin de famille canadien·2011

    Area of Science:

    • Genetics and Immunology
    • Gastroenterology

    Background:

    • Familial predisposition to inflammatory bowel disease (IBD), including Crohn's disease, is recognized.
    • Previous research suggests a potential link between IBD susceptibility and the Human Leukocyte Antigen (HLA) gene locus.

    Observation:

    • A family with five children was studied, with at least four exhibiting Crohn's disease.
    • HLA typing was performed on four affected siblings.

    Findings:

    • Three siblings shared identical paternal (A2, B44) and maternal (A30, B17) haplotypes.
    • Three of the four siblings were HLA identical.
    • Analysis of this family and four literature studies showed a trend towards shared HLA haplotypes in affected siblings, but it lacked statistical significance.

    Implications:

    • The study suggests a possible, but not statistically confirmed, association between HLA gene locus and Crohn's disease susceptibility.
    • Further research is needed to definitively establish the role of HLA genes in familial Crohn's disease.
    • The presence of lymphocytotoxic antibodies in affected children warrants further investigation.

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