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Cognitive-behavior therapy for chronically depressed patients. A controlled pilot study

R E Harpin, R P Liberman, I Marks

    The Journal of Nervous and Mental Disease
    |May 1, 1982
    PubMed
    Summary
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    Cognitive-behavior therapy significantly improved social skills and reduced depression and anxiety in chronically depressed outpatients. These gains were maintained at 6-month follow-up, indicating therapy

    Area of Science:

    • Psychiatry
    • Clinical Psychology

    Background:

    • Chronic depression often shows resistance to standard treatments.
    • Alternative therapies are needed for treatment-resistant depression.

    Purpose of the Study:

    • To evaluate the efficacy of cognitive-behavior therapy (CBT) for chronically depressed outpatients unresponsive to other treatments.

    Main Methods:

    • A pilot study with 12 treatment-resistant depressed outpatients.
    • Random assignment to CBT (twice weekly for 10 weeks) or a waiting list control.
    • Outcome measured by self-report, clinical ratings, and behavioral observation of social skills and depressive affect.

    Main Results:

    • The CBT group showed significant improvements in depression, anxiety, and social skills post-treatment.

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  • Improvements in anxiety and social skills were sustained at 6-month follow-up.
  • No significant differences were found between groups at 6-month follow-up in this small sample.

    • Conclusions:

    • Cognitive-behavior therapy shows promise for improving outcomes in treatment-resistant depression.
    • Further research with larger samples is warranted to confirm these findings.