Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interactions between folate and ascorbic acid in the guinea pig

C M Lewis, E L McGown, M G Rusnak

    The Journal of Nutrition
    |April 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants.

    Molecular psychiatry·2024
    Same author

    Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants.

    medRxiv : the preprint server for health sciences·2024
    Same author

    Search for a Nonrelativistic Boson in Two-Body Antimuon Decay.

    Physical review letters·2024
    Same author

    Measurement of Coherent Elastic Neutrino-Nucleus Scattering from Reactor Antineutrinos.

    Physical review letters·2022
    Same author

    Stroke: A retrospective review of the incidence and epidemiology in a South African academic hospital emergency department.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2021
    Same author

    Locked down: Impact of COVID-19 restrictions on trauma presentations to the emergency department.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2021
    Same journal

    Evaluation of Energy and Nutrient Estimates from Large Language Models Using Text-Based Queries.

    The Journal of nutrition·2026
    Same journal

    Considerations for Dietary Supplements After GLP-1RA Treatment: A Narrative Review.

    The Journal of nutrition·2026
    Same journal

    The apple(juice) doesn't fall far from the tree: Children's hydration mirrors their parent's.

    The Journal of nutrition·2026
    Same journal

    Microbial-derived polyphenol metabolites and the gut microbiota: A scoping review of clinical studies.

    The Journal of nutrition·2026
    Same journal

    Hesperidin as an Emerging Nutraceutical in Modern Health and Preventive Medicine: A Narrative Review.

    The Journal of nutrition·2026
    Same journal

    Short-Chain Fatty Acids in Livestock and Aquatic Animals: Metabolic Divergence, Physiological Functions, and Product Development.

    The Journal of nutrition·2026
    See all related articles

    Folate and ascorbic acid (AA) interactions were studied in guinea pigs. Folate deficiency unexpectedly lowered AA levels in some tissues, suggesting a link between these essential vitamins.

    Area of Science:

    • Biochemistry
    • Nutrition Science
    • Human Physiology

    Background:

    • Interactions between folic acid (folate) and ascorbic acid (AA) are suspected due to anemia in scorbutic patients.
    • The potential impact of AA on folate metabolism and vice versa requires further investigation.

    Purpose of the Study:

    • To investigate the interaction between folate and AA in a controlled animal model.
    • To determine if AA deficiency affects folate levels or exacerbates folate deficiency symptoms.
    • To assess the impact of folate deficiency on AA levels.

    Main Methods:

    • Male weanling guinea pigs were fed diets with varying levels of folate and AA.
    • Tissue samples (blood, liver, adrenal, kidney, spleen, intestinal mucosa) were analyzed for AA and folate.

    Related Experiment Videos

  • Control groups received adequate levels of both vitamins.

    • Main Results:

    • Folate and AA deficiencies reduced their respective tissue levels.
    • AA deficiency did not impact tissue folate levels or worsen anemia/leukopenia from folate deficiency.
    • Folate deficiency led to an unexpected decrease in AA levels in liver and adrenal tissues.

    Conclusions:

    • Ascorbic acid does not appear essential for normal folate metabolism.
    • Folate deficiency is associated with reduced tissue AA levels, indicating a significant interaction between the two vitamins.
    • Further research is needed to elucidate the mechanisms behind this observed interaction.