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Malignant melanoma with unknown primary site

R Lopez, E D Holyoke, R H Moore

    Journal of Surgical Oncology
    |March 1, 1982
    PubMed
    Summary
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    Malignant melanoma of unknown primary site is a significant diagnosis. Radical surgical excision for regional disease offers survival rates comparable or better than for known primary sites.

    Area of Science:

    • Oncology
    • Dermatology
    • Surgical Oncology

    Background:

    • Metastatic malignant melanoma from an unknown primary site represents a notable proportion of melanoma cases.
    • A significant majority of patients present with palpable masses or lumps.

    Purpose of the Study:

    • To evaluate the survival outcomes for patients with metastatic malignant melanoma of unknown primary origin.
    • To determine the efficacy of surgical intervention for regional disease in this patient cohort.

    Main Methods:

    • Retrospective analysis of 129 patients diagnosed with metastatic malignant melanoma from an unknown primary site between 1955 and 1976.
    • Comparison of survival rates based on lesion location and treatment modality, particularly focusing on surgical excision for regional disease.

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    Main Results:

    • The overall median survival was 10 months, with a 5-year survival rate of 13%.
    • Patients with head and neck lesions had a 5-year disease-free survival of 25%, while those with lymph node disease had an 18% survival rate.
    • Twenty-nine patients with regional disease treated with wide excision (lymphadenectomy) achieved a 5-year disease-free survival of 58%.

    Conclusions:

    • Radical surgical excision is recommended for regional disease in patients with malignant melanoma of unknown primary site.
    • Surgical treatment for regional disease in this context yields survival outcomes that are comparable or superior to those with a known primary site.