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Related Experiment Videos

Tissue reaction to prosthetic obturator materials

K Kent, W A Beecroft, U Roa

    Journal of Surgical Oncology
    |March 1, 1982
    PubMed
    Summary

    Poly(methyl methacrylate) and poly(dimethyl siloxane) are used for maxillary obturators. Both materials showed similar tissue responses, but poly(dimethyl siloxane) offered a better clinical outcome for patients.

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    Area of Science:

    • Biomaterials Science
    • Oral and Maxillofacial Surgery
    • Tissue Engineering

    Background:

    • Major maxillary defects often require obturators to restore function.
    • Poly(methyl methacrylate) (PMMA) and poly(dimethyl siloxane) (PDMS) are primary materials for obturator construction.
    • Understanding the tissue response to these materials is crucial for patient outcomes.

    Purpose of the Study:

    • To compare the histologic and clinical tissue responses to PMMA and PDMS obturators in primate models.
    • To evaluate the suitability of PMMA and PDMS for obturators used in major maxillary defects.

    Main Methods:

    • Maxillectomies were performed on primate subjects.
    • Obturators constructed from PMMA and PDMS were placed in contact with antral and nasal mucosa.
    • Serial biopsies and clinical evaluations were conducted to assess tissue response.

    Main Results:

    • Histologic examination revealed comparable tissue responses to both PMMA and PDMS.
    • Clinical evaluations indicated a more favorable tissue response to PDMS compared to PMMA.
    • Both materials demonstrated acceptable biocompatibility in the context of obturator use.

    Conclusions:

    • PDMS may be a preferable material for maxillary obturators due to its superior clinical tissue response.
    • Further research can explore long-term outcomes and patient-specific material selection.
    • Both PMMA and PDMS are viable options, but PDMS shows a clinical advantage.

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