Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spatial ability in androgen-deficient men

D B Hier, W F Crowley

    The New England Journal of Medicine
    |May 20, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Men with idiopathic hypogonadotropic hypogonadism show impaired spatial ability. This suggests androgens permanently organize the brain during male development before puberty.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Factors predicting 30-day mortality in the Warsaw stroke registry.

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
    Same author

    Influence of site on course of intracerebral hemorrhage.

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
    Same author

    Analysis of 30-day stroke mortality in a community-based registry in Warsaw, Poland.

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
    Same author

    Functional consequences of AXL sequence variants in hypogonadotropic hypogonadism.

    The Journal of clinical endocrinology and metabolism·2014
    Same author

    Translational careers.

    Science (New York, N.Y.)·2009
    Same author

    CHD7 mutations in patients initially diagnosed with Kallmann syndrome--the clinical overlap with CHARGE syndrome.

    Clinical genetics·2008
    Same journal

    Ebola at 50 - Lessons for Outbreak Response and Preparedness.

    The New England journal of medicine·2026
    Same journal

    Ianalumab plus Eltrombopag in Immune Thrombocytopenia. Reply.

    The New England journal of medicine·2026
    Same journal

    Ianalumab plus Eltrombopag in Immune Thrombocytopenia.

    The New England journal of medicine·2026
    Same journal

    Hypertension Control in Low-Income Patients. Reply.

    The New England journal of medicine·2026
    Same journal

    Hypertension Control in Low-Income Patients.

    The New England journal of medicine·2026
    Same journal

    Hypertension Control in Low-Income Patients.

    The New England journal of medicine·2026
    See all related articles

    Area of Science:

    • Neuroendocrinology
    • Cognitive Neuroscience
    • Human Physiology

    Background:

    • Androgens are known to influence cognitive functions.
    • Idiopathic hypogonadotropic hypogonadism (IHH) presents a unique model to study androgen effects on cognition.
    • The timing of androgen exposure may be critical for brain development.

    Purpose of the Study:

    • To investigate the impact of androgen deficiency on spatial cognitive abilities in men with IHH.
    • To compare spatial abilities in men with IHH, acquired hypergonadotropic hypogonadism, and healthy controls.
    • To explore the role of androgen exposure timing in cognitive development.

    Main Methods:

    • Comparative study involving 19 men with IHH, 19 controls, and 5 men with acquired hypergonadotropic hypogonadism.

    Related Experiment Videos

  • Assessment of spatial ability in all participant groups.
  • Correlation analysis between spatial ability and testicular volume in IHH patients.
  • Evaluation of androgen-replacement therapy effects on spatial ability in a subset of IHH patients.

    • Main Results:

    • Men with IHH exhibited significantly impaired spatial ability compared to controls and men with acquired hypogonadism.
    • Spatial ability in IHH patients positively correlated with testicular volume.
    • Androgen-replacement therapy did not improve spatial deficits in IHH patients.
    • Men with acquired hypogonadism did not show spatial impairments.

    Conclusions:

    • Androgens appear to exert a permanent organizing effect on brain regions underlying spatial ability during male development before or at puberty.
    • The timing of androgen action is crucial for establishing normal cognitive function, particularly spatial skills.
    • Early-life androgen exposure is critical for the permanent organization of cognitive functions in males.