Partial purification and characterization of lenticular S-adenosylmethionine synthetase

Lenticular S-adenosylmethionine synthetase has been partially purified and characterized. Lower levels of S-adenosylmethionine synthetase were detected by a sensitive radioactive assay procedure in the lenticular extract obtained from the pooled lenses of alloxan-treated rats 96 days of age as compared to the nontreated controls. With respect to chromatographic behavior and kinetic analysis, lenticular S-adenosylmethionine synthetase closely resembled that of the corresponding liver enzyme.