[On the compression behaviour of spray-dried sulphathiazole (author's transl)]

The authors prepared a spray-dried sulphathiazole product consisting of hollow pellets, the drug being in the form of its metastable modification I (melting point, 200 degrees C). On the basis of force-time diagrams and of current parameters relative to the elasto-plastic deformability of substances intended for tabletting, the compression behaviour of the spraydried product was compared with that of sulphathiazole (modification I) tempered at 180 degrees C for 150 min. Scanning-electron-microscopic studies on tablet surfaces offered further insight into the compressibility of the spraydried product.