Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcitonin secretion in hyperthyroidism

L Gozariu, I Duncea, O Florescu

    Endocrinologie
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Clinical-functional considerations in the association of rheumatoid polyarthritis with chronic hepatitis C.

    Journal of medicine and life·2019
    Same author

    [Mediastinal giant cystic dysembrioma].

    Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2015
    Same author

    Contrast-enhanced ultrasound (CEUS) for the evaluation of focal liver lesions - a prospective multicenter study of its usefulness in clinical practice.

    Ultraschall in der Medizin (Stuttgart, Germany : 1980)·2014
    Same author

    Nutritional risk screening and prevalence of malnutrition on admission to gastroenterology departments: a multicentric study.

    Chirurgia (Bucharest, Romania : 1990)·2013
    Same author

    McKittrick-Wheelock syndrome: a rare etiology of acute renal failure associated to well-differentiated adenocarcinoma (G1) arising within a villous adenoma.

    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie·2011
    Same author

    Pathologic crossroads: cardio-vascular diseases, periodontal diseases and calcium antagonists.

    Journal of medicine and life·2011
    Same journal

    [Bioethics in Romania. Science is a challenge, bioethics is a response].

    Endocrinologie·1991
    Same journal

    Changes in the iodine content of vegetables following the Chernobyl accident.

    Endocrinologie·1991
    Same journal

    Epidemiological surveillance of iodine deficiency in Romania by urinary iodine determinations in children aged 6-16 years from 30 counties.

    Endocrinologie·1991
    Same journal

    Cardiac disturbances in thyrotoxicosis: diagnosis, incidence, clinical features and management.

    Endocrinologie·1991
    Same journal

    Melatonin involvement in oxidative processes.

    Endocrinologie·1991
    Same journal

    Influence of sex and glucocorticoid hormones on 3H cholesterol uptake in the aortic wall and 3H adrenaline in the brain.

    Endocrinologie·1991
    See all related articles

    Hyperthyroid patients show altered calcitonin secretion. While basal levels are often normal, pentagastrin stimulation reveals a responsive calcitonin-secreting system, potentially aiding skeletal protection.

    Area of Science:

    • Endocrinology
    • Calcium Metabolism
    • Thyroid Disorders

    Background:

    • Hyperthyroidism can affect calcium homeostasis.
    • Calcitonin plays a role in bone metabolism and calcium regulation.
    • The calcitonin secretory capacity in hyperthyroidism requires further elucidation.

    Purpose of the Study:

    • To investigate calcitonin secretion in hyperthyroid patients.
    • To assess the responsiveness of the calcitonin-secreting system to stimulation.
    • To explore the potential role of calcitonin in skeletal protection in hyperthyroidism.

    Main Methods:

    • Radioimmunoassay (RIA) method used to measure calcitonin levels.
    • Study involved 45 hyperthyroid patients.
    • Stimulation tests included calcium loading (slow and rapid) and pentagastrin injection.

    Related Experiment Videos

    Main Results:

    • Basal calcitonin secretion exceeded 500 pg/ml in only 7 out of 45 patients.
    • Slow calcium loading increased mean calcitonin levels with variable individual responses.
    • Pentagastrin injection induced a significant secretory peak (over 1,800 pg/ml) in 4 out of 5 patients.

    Conclusions:

    • The calcitonin-secreting system in hyperthyroidism demonstrates responsiveness, particularly to pentagastrin.
    • Elevated calcitonin levels are not consistently observed basally.
    • Calcitonin may play a protective role in the skeleton of hyperthyroid individuals.