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[Invasive isolated pulmonary cryptococcosis. Case report]

M Blanc, P Leuenberger, G Favez

    Schweizerische Medizinische Wochenschrift
    |March 20, 1982
    PubMed
    Summary
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    A man with suspected sarcoidosis developed a fever and worsening respiratory symptoms despite antibiotic treatment. Autopsy revealed invasive pulmonary cryptococcosis, a fungal infection, as the cause of death.

    Area of Science:

    • Pulmonology
    • Infectious Diseases
    • Pathology

    Background:

    • Sarcoidosis is an inflammatory disease often affecting the lungs, characterized by granulomas.
    • Diagnosis can be challenging, sometimes requiring invasive procedures like lung biopsies.
    • Fungal infections can present with similar symptoms to other pulmonary conditions.

    Observation:

    • A 57-year-old male presented with progressive respiratory distress and bilateral infiltrates.
    • Transbronchial lung biopsies showed non-caseating epithelioid granulomas, raising suspicion for sarcoidosis.
    • Elevated antibodies against Kveim antigen further supported the sarcoidosis diagnosis.

    Findings:

    • The patient's temperature increased one month after initiating steroid treatment.

    Related Experiment Videos

  • Broad-spectrum antibiotics were ineffective in treating the patient's condition.
  • Autopsy revealed invasive isolated pulmonary cryptococcosis as the definitive diagnosis.

    • Implications:

    • This case highlights the importance of considering opportunistic fungal infections in immunocompromised or steroid-treated patients.
    • Diagnostic challenges in pulmonary diseases necessitate a broad differential diagnosis.
    • Pulmonary cryptococcosis can mimic other granulomatous lung diseases, leading to delayed diagnosis and treatment.