Neutrophilic movement of a Basenji with Pelger-Huët anomaly

Random and chemotactic neutrophilic movements in a Basenji with Pelger-Huët (P-H) anomaly was compared with such movement in 5 healthy control dogs. Duplicate samples of neutrophils were quantitated after 5, 10, 15, 30, and 45 minutes of incubation. On the basis of population mean responses, no significant difference (P greater than 0.05) was found between P-H and control neutrophils for any type of movement at any time interval examined. These findings indicate that the movement of neutrophils with P-H anomaly may be unaffected by the nuclear abnormality.