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Cefamandole treatment of Salmonella bacteremia
Antimicrobial Agents and Chemotherapy
|February 1, 1982
Abstract:
The efficacy of cefamandole in the treatment of 19 patients with salmonella bacteremia was evaluated. Although all of the salmonella strains isolated were highly susceptible to cefamandole in vitro, a therapeutic failure was observed in 7 (36.8%) of the 19 patients.
Insights
Cefamandole showed high in vitro susceptibility against Salmonella strains. However, clinical treatment failed in 36.8% of patients with salmonella bacteremia, indicating a discrepancy between laboratory results and patient outcomes.
Area of Science:
- Infectious Diseases
- Pharmacology
- Microbiology
Background:
- Salmonella bacteremia poses a significant clinical challenge.
- Antibiotic resistance in Salmonella necessitates evaluation of therapeutic options.
Purpose of the Study:
- To assess the clinical efficacy of cefamandole in treating salmonella bacteremia.
- To compare in vitro cefamandole susceptibility with in vivo treatment outcomes.
Main Methods:
- Evaluation of cefamandole treatment in 19 patients diagnosed with salmonella bacteremia.
- In vitro susceptibility testing of isolated Salmonella strains against cefamandole.
Main Results:
- All isolated Salmonella strains demonstrated high in vitro susceptibility to cefamandole.
- Therapeutic failure occurred in 7 out of 19 (36.8%) patients treated with cefamandole.
Conclusions:
- Cefamandole's in vitro susceptibility does not guarantee clinical success in treating salmonella bacteremia.
- Further investigation is needed to understand the reasons for therapeutic failure despite in vitro sensitivity.