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Related Experiment Videos

Hypercalcemia associated with gynecologic malignancies: biochemical characterization

A F Stewart, R Romero, P E Schwartz

    Cancer
    |June 1, 1982
    PubMed
    Summary

    Gynecologic cancers frequently cause hypercalcemia through humoral mechanisms, indicating a large tumor burden. Eradicating the tumor, not just treating hypercalcemia, resolves this humoral syndrome.

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    Area of Science:

    • Oncology
    • Endocrinology
    • Nephrology

    Background:

    • Malignancy-associated hypercalcemia is a serious complication.
    • Gynecologic neoplasms are an underrecognized cause of this condition.

    Purpose of the Study:

    • To investigate the mechanisms and characteristics of hypercalcemia in patients with gynecologic neoplasms.
    • To assess the role of humoral factors in malignancy-associated hypercalcemia.

    Main Methods:

    • Assessed fasting calcium excretion, renal phosphorus threshold, plasma 1,25 dihydroxyvitamin D, immunoreactive PTH, and nephrogenous cyclic AMP excretion.
    • Evaluated tumor burden and histological features in nine patients with gynecologic neoplasms and hypercalcemia.

    Main Results:

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  • Gynecologic neoplasms caused hypercalcemia in 20.5% of patients with malignancy-associated hypercalcemia.
  • All patients exhibited biochemical evidence of humorally mediated hypercalcemia (bone resorption).
  • Squamous features were frequent in hypercalcemic endometrial carcinomas.

    • Conclusions:

    • Gynecologic neoplasms are a significant cause of malignancy-associated hypercalcemia.
    • Humoral mechanisms are responsible for hypercalcemia in these cases, associated with a large tumor burden.
    • Tumor eradication, not hypercalcemia treatment, resolves the humoral syndrome.