Related Experiment Video

Updated: Jun 23, 2026

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation
07:52

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

Published on: July 23, 2012

Short stature and delayed skeletal maturation in children with allergic disease

A C Ferguson, A B Murray, W J Tze

    The Journal of Allergy and Clinical Immunology
    |May 1, 1982
    PubMed

    Insights

    Short stature is common in children with allergic respiratory diseases like asthma. These children often have good growth potential, suggesting underlying atopic conditions may affect height, not just asthma itself.

    Area of Science:

    • Pediatric Endocrinology
    • Allergology
    • Genetics

    Background:

    • Short stature is a concern in pediatric health.
    • Asthma and allergic rhinitis are common conditions in children.
    • The relationship between allergic respiratory diseases and growth is not fully understood.

    Purpose of the Study:

    • To determine the frequency of short stature in children with asthma or allergic rhinitis.
    • To investigate the characteristics of children with short stature and allergic respiratory disease.
    • To explore potential causes of impaired linear growth in this population.

    Main Methods:

    • Cross-sectional study of 598 children referred for asthma or allergic rhinitis.
    • Assessment of height, bone age, and hormonal levels in children with short stature (height < 3rd percentile).
    • Comparison of growth parameters between asthmatic and non-asthmatic children.

    Main Results:

    • Six percent of referred children had short stature.
    • Children with short stature were predominantly male, exhibiting delayed bone age and normal growth hormone secretion.
    • Impaired linear growth was observed in both asthmatic and non-asthmatic children, unrelated to asthma severity.
    • Thyroid hormone levels showed normal thyroxine but elevated tri-iodothyronine.

    Conclusions:

    • Short stature is more prevalent than expected in children with allergic respiratory diseases.
    • Growth potential appears good, suggesting factors beyond asthma contribute to short stature.
    • The atopic state may be linked to a fundamental abnormality affecting linear growth.
    • Allergic respiratory disease warrants consideration in the evaluation of pediatric short stature.

    More Related Videos

    Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts07:56

    Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

    Published on: January 29, 2018

    Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model08:03

    Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

    Published on: November 4, 2025

    Related Concept Videos

    Nature and Nurture01:10

    Nature and Nurture

    Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience, such as differences...
    Asthma: Pathogenesis and Management01:20

    Asthma: Pathogenesis and Management

    Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
    Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
    Signs of Puberty01:27

    Signs of Puberty

    Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
    Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

    Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

    Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
    Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

    Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

    Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
    Asthma I: Introduction01:28

    Asthma I: Introduction

    Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...