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Atypical lipoma

L G Kindblom, L Angervall, A S Fassina

    Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Atypical lipomas are well-differentiated liposarcomas with moderate nuclear atypia. These tumors can recur but do not metastasize or dedifferentiate, requiring careful histological review for accurate diagnosis.

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    Area of Science:

    • Surgical Pathology
    • Oncology
    • Soft Tissue Tumors

    Background:

    • A previous study suggested 'atypical lipoma' for well-differentiated liposarcomas with moderate nuclear atypia.
    • This designation was proposed for non-metastasizing liposarcomas.

    Purpose of the Study:

    • To describe 21 new cases of atypical lipoma.
    • To further characterize the clinicopathologic features and behavior of atypical lipomas.

    Main Methods:

    • Histopathological examination of 21 new cases.
    • Ultrastructural analysis of two tumors.
    • Review of clinical data including location, recurrence, and treatment.

    Main Results:

    • Tumors composed of univacuolated fat cells with some showing enlarged, moderately polymorphic nuclei.

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  • Occasional multinucleated cells and delicate fibrosis with atypical nuclei were noted.
  • Nine tumors were intramuscular, two intermuscular, and ten subcutaneous; recurrence was observed in 8/21 cases, particularly subcutaneous ones.
  • Ultrastructural findings supported a neoplastic nature of nuclear polymorphism.
  • No metastasis or dedifferentiation was observed at recurrence.

    • Conclusions:

    • Atypical lipoma represents a distinct entity within well-differentiated liposarcomas.
    • Recurrence is possible, often due to initial misdiagnosis as ordinary lipoma.
    • Careful histological evaluation is crucial for identifying nuclear atypia and distinguishing atypical lipoma from benign lipoma.