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Surface structure of intravasculary megakaryocytes. A scanning electron microscope study
Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology
|January 1, 1982
Summary
Intravascular megakaryocytes in rabbits are spherical and highly folded, lacking pseudopods. Their naked nuclei appear irregular due to residual cytoplasm, resembling blebs.
Area of Science:
- Hematology
- Cell Biology
Background:
- Megakaryocytes are crucial for platelet production.
- Understanding megakaryocyte surface morphology is key to platelet formation.
Purpose of the Study:
- To investigate the surface structure of intravasculary located megakaryocytes.
- To characterize the morphology of rabbit megakaryocytes in their native vascular environment.
Main Methods:
- Rabbit megakaryocytes were isolated from central venous blood.
- Scanning electron microscopy was employed for detailed surface examination.
Main Results:
- Megakaryocytes were approximately 50 micrometers in diameter and spherical.
- The cell surface exhibited extensive folding with ridges and clefts.
- No pseudopods (budding structures) were observed on the megakaryocyte surface.
- Naked megakaryocyte nuclei (15-20 micrometers) appeared irregular due to residual cytoplasm, resembling blebs.
Conclusions:
- Intravascular megakaryocytes possess a unique, highly folded surface morphology.
- The absence of pseudopods suggests a distinct surface behavior in the vascular space.
- Residual cytoplasm on nuclei may contribute to their irregular appearance.