[Primary biliary liver cirrhosis with a granulomatous reaction]

An observation of primary biliary hepatocirrhosis with granulomatous reaction in a woman of 50 is presented. The disease for 3 years was accompanied by hepatic cholestasis. Diagnostic laparotomy done to exclude the mechanical nature of cholestasis revealed cholecystolithiasis, and cholecystectomy was performed. The material of marginal intraoperational liver biopsy revealed chronic nonsuppurative destructive cholangitis, proliferation of biliary tubules and periductullar fibrosis, granulomas containing giant multinuclear cells of Pirogov-Langhans type, and morphological signs of chronic active hepatitis.