Removable fluid-containing chamber for in vivo guinea pig skin studies

A removable, fluid-tight chamber is discussed that may be used to measure ion flux through the skin. This chamber adheres to clipped guinea pig skin with the use of silicone rubber adhesive, where hair stubble facilitates attachment. The technique also should work well for other hairy species. Experiments may be performed on hairless skin provided the adhesive is incompletely cured and the chamber is held in place by a strap.