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An interaction study between benoxaprofen and digoxin

B Zöller, H J Engel, G Faust-Tinnefeldt

    European Journal of Rheumatology and Inflammation
    |January 1, 1982
    PubMed
    Summary
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    Benoxaprofen maintenance therapy did not affect digoxin levels in patients with rheumatic disease. This non-steroidal anti-inflammatory drug showed no impact on digoxin efficacy or safety, even with altered renal function.

    Area of Science:

    • Pharmacology and Therapeutics
    • Rheumatology

    Background:

    • Digoxin is a crucial medication for managing heart conditions, requiring careful monitoring of plasma levels.
    • Non-steroidal anti-inflammatory drugs (NSAIDs) like benoxaprofen are frequently used in patients with rheumatic diseases, raising concerns about potential drug interactions.

    Purpose of the Study:

    • To investigate the influence of maintenance therapy with benoxaprofen on steady-state digoxin plasma levels.
    • To assess the safety and efficacy of concomitant benoxaprofen and digoxin use in patients with rheumatic disease.

    Main Methods:

    • A study involving 12 patients with rheumatic disease receiving maintenance therapy with benoxaprofen (600 mg daily).
    • Digoxin steady-state plasma levels were monitored during concomitant therapy and after benoxaprofen withdrawal.

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  • Renal function values were assessed to evaluate kidney function changes.

    • Main Results:

    • No statistically significant difference was observed in digoxin plasma levels during concomitant benoxaprofen therapy (p > 0.10).
    • Digoxin levels remained unchanged after benoxaprofen withdrawal (p > 0.90).
    • No toxic digoxin concentrations were detected, and renal function remained stable throughout the study.

    Conclusions:

    • Maintenance therapy with benoxaprofen at 600 mg daily does not significantly alter digoxin steady-state plasma levels in patients with rheumatic disease.
    • Concomitant use of benoxaprofen and digoxin appears safe, with no observed impact on digoxin efficacy or renal function.