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Related Experiment Videos

Propranolol in children: safety-toxicity

M Artman, M Grayson, R C Boerth

    Pediatrics
    |July 1, 1982
    PubMed
    Summary

    Propranolol is generally safe in children, even at high doses. However, children on chronic propranolol therapy require monitoring for hypoglycemia, especially when caloric intake is reduced.

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    Area of Science:

    • Pediatric Pharmacology
    • Cardiovascular Therapeutics
    • Adverse Drug Events

    Background:

    • Propranolol is a beta-blocker medication used for various pediatric conditions.
    • Assessing propranolol's safety profile in children is crucial for effective therapeutic use.
    • Understanding potential adverse effects, such as hypoglycemia, is essential for patient management.

    Observation:

    • A healthy 3-year-old boy experienced very high plasma propranolol concentrations (2,289 ng/ml) after acute ingestion, with only a diminished heart rate response.
    • A 4-year-old boy on chronic propranolol therapy for renovascular hypertension developed hypoglycemia and seizure after refusing food for three days due to an oral wound.

    Findings:

    • Acute, high-dose propranolol exposure in a healthy child did not result in severe adverse effects.
    • Impaired caloric intake in children on chronic propranolol therapy can precipitate hypoglycemia, requiring prompt medical intervention.

    Implications:

    • Propranolol appears to have a wide safety margin in acute pediatric overdose scenarios.
    • Vigilance for hypoglycemia is critical in pediatric patients receiving chronic propranolol, particularly during periods of reduced food intake.
    • This highlights the importance of individualized monitoring and management strategies for pediatric patients on beta-blocker therapy.

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