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Trigeminal neuropathy in progressive systemic sclerosis

D A Farrell, T A Medsger

    The American Journal of Medicine
    |July 1, 1982
    PubMed
    Summary
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    Trigeminal neuropathy affects 4% of patients with progressive systemic sclerosis (PSS). It is more common in young women with PSS, particularly those with mixed connective tissue disease and myositis.

    Area of Science:

    • Rheumatology
    • Neurology

    Background:

    • Progressive systemic sclerosis (PSS) is a multisystem autoimmune disease.
    • Trigeminal neuropathy is a potential complication of PSS.

    Purpose of the Study:

    • To investigate the prevalence and characteristics of trigeminal neuropathy in patients with PSS.
    • To identify associated clinical and serological features of PSS with trigeminal neuropathy.

    Main Methods:

    • Retrospective review of 442 consecutive PSS patients evaluated between 1972 and 1980.
    • Comparison of PSS patients with and without trigeminal neuropathy.
    • Analysis of clinical data and serological markers, including antibodies to ribonucleoprotein.

    Main Results:

    • Trigeminal neuropathy was identified in 16 (4%) of 442 PSS patients.

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  • It was more frequent in young women with PSS, especially those with overlap syndromes like mixed connective tissue disease and myositis.
  • Associated conditions included leukopenia, hypothyroidism, and Sjögren's syndrome.
  • Serum antibodies to ribonucleoprotein were more prevalent in PSS patients with trigeminal neuropathy (45%) compared to those without (8%).

    • Conclusions:

    • Trigeminal neuropathy is an uncommon but significant complication of PSS.
    • It is associated with specific clinical features and serological markers, suggesting distinct pathophysiological pathways.